Napos Database

Acute Porphyria Drugs

Risk Classification of Drugs

More detailed clinical advice is available in the table, in the "Read more..." link. There is a printable "Clinical Actions" PDF-file, but it's only available in English.
Class
 Interpretation
Advice1
Advice1
NP
Not Porphyrinogenic
No precautions needed.
Use
Risk.USE 2
PNP
Probably Not Porphyrinogenic
No precautions needed.
Use
PSP
Possibly Porphyrinogenic
Low risk. Use only when there is no safe alternative, and the benefit outweighs the risk.
Caution
Risk.CAUTION
PRP
Probably Porphyrinogenic
High risk. Use only when benefit strongly outweighs risk and a safer alternative is not available.
Avoid
Risk.AVOID 2
P
Porphyrinogenic
High risk. Use only when benefit strongly outweighs risk and a safer alternative is not available.
Avoid
NC
Not Yet Classified
Risk unknown, use a safe alternative.
Caution
Risk.CAUTION
  1. Relevant only to the acute hepatic porphyrias (acute intermittent porphyria, variegate porphyria, hereditary coproporphyria and ALA dehydratase deficiency porphyria).
  2. Although pharmacologically different classifications, the clinical approach is the same.
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