Not CYP-metabolised. No data pointing to induction or inhibition of CYPs. Several references state non-porphyrinogenicity. The daily dose is beneath the mg range and hepatocyte exposure beneath the micromolar range.

Heart glycoside used in cardiac insufficiency and cardiac arrythmias.

The daily dose is beneath the mg range and hepatocyte exposure beneath the micromolar range.

Although digoxin is reported to be excreted mainly unchanged in the urine there is evidence to suggest that metabolism may sometimes be extensive. Metabolites that have been detected in the urine include digoxigenin, dihydrodigoxigenin, the mono- and bisdigitoxosides of digoxigenin, and dihydrodigoxin. The metabolism of digoxin is not dependent upon the cytochrome P-450 system. Digoxin is not known to induce or inhibit the cytochrome P-450 system.

Andersson, clinical observation (n=1) tolerated.

Uneventful use reported in 3 patients with acute porphyria.