R06AX13 - Loratadine

Probably Not Porphyrinogenic

Rationale

Metabolised by CYP3A4. Inducer of CYP3A4. Two references consider it safe.

Chemical description

Antihistamine without sedative effect used (10 mg/d p.o.) in allergic rhinitis/conjunctivitis and in histamine mediated pruritus and urticaria. The same general structure as cyproheptadine (PSP). Metabolized by CYP3A4. Main metabolite is decarboxyethoxyloratidine with an elimination half time of 19 hours.

Personal communication

Clinical experience (Swedish) seems to point to non-porphyrinogenicity. Thunell: occasionally observed to be tolerated. Andersson, patient reports: tolerated (n=13). Andersson C, patient reports: tolerated (n=4).

Ipnet drug reports

Uneventful use reported in 28 patients with acute porphyria.

Similar drugs

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R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AX Other Antihistamines for Systemic use

References

#	Citation details	PubMed ID
Porphyria Drug Lists
1.	French List Centre Français des Porphyries
2.	South African List Porphyria South Africa No longer maintained

Tradenames

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Allergex nd · ap-Loratadine · Cipla Loratadine · Clarinese · Clarityne · Demazin Once a day · Disc Clarityne · Laura · Lorano · Loratadine Ascend · Loratidine Austell · Lordyno · Lorfast · Pollentyme · Pollentyme s · Rhineton non Drowsy · Rhinigine

Allerfre · Claritine · Lorastad · Loratadine

Claritine · Loratadine

Clarityne · Loratadine

Civerán · Clarityne · Loratadina

Claritine · Erolin · Loratadin

Clarityn · Fristamin · Loratadina

Alerityn · Claritine · Flonidan · Lorastamin · Loratadin · Loratadina · Proactin · Symphoral

Claritine · Lora · Lorado · Loratadin

Bell's Children's Allergy Relief · Bell's Hayfever & Allergy Relief · Boots One A Day Allergy Relief · Brown & Burk Once-A-Day Hayfever & Allergy · Clarityn · Clarityn Allergy · Clarityn Rapide Allergy · Galpharm Non-Drowsy Allergy Relief · Galpharm Non-Drowsy Hayfever and Allergy Relief · Hay-Rite Allergy · Lloydspharmacy Non-Drowsy Allergy Relief · Lorapaed Allergy Relief · Loratadine · Numark Allergy & Hayfever · Roletra