R03AA01 - Epinephrine |
Not porphyrinogenic |
NP |
Mono.Rationale
Epinephrine (adrenaline) is an endogenous catecholamine with non-CYP dependent metabolism. There are no data pointing to CYP-interaction.
Mono.ChemicalDescription
Endogenous catecholamine.
Mono.TherapeuticCharacteristics
Epinephrine (adrenaline) is a catecholamine used in asthma bronchiale, cardiac arrest, hypersensitivity reactions. Parenterally administered in 0.3-1 mg dose.
Mono.MetabolismAndPharmacokinetics
Epinephrine (adrenalin) is an endogenous compound. It is very rapidly inactivated by processes which include uptake into adrenergic neurones, diffusion, and enzymatic degradation in the liver and body tissues. Metabolism involves monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT).
Mono.IpnetDrugReports
Uneventful use reported in 5 patients with acute porphyria, in combination with local anaesthetics.
Mono.SimilarDrugs
Mono.References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Porphyrias.
James MF, Hift RJ. Br J Anaesth. 2000 Jul; 85(1):143-53.
|
10928003 |
| Drug reference publications | ||
| 2. | Sweetman SC, editor. Martindale: The complete drug reference. Adrenaline. Pharmaceutical Press 2009.
|
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Mono.Tradenames
Asthmanefrin 
Micronefrin · S2- Racepinephrine 
Asthmanefrin · S2 Racepinephrine 
Adrenaline · Adrenaline Auto · Adrenaline Auto -JV · Medihaler-Epi