L01FD01 - Trastuzumab |
Not porphyrinogenic |
NP |
Mono.Rationale
No CYP-affinity. No conceivable effects on PXR activation. However, side effects such as nausea and vomiting may be potentially porphyrinogenic through reduction in caloric intake.
Mono.ChemicalDescription
Trastuzumab is a recombinant DNA-derived humanized anti-HER2 monoclonal antibody.
Mono.TherapeuticCharacteristics
Trastuzumab is an antineoplastic agent used in the treatment of breastcancer. It is administered as an intravenous infusion. Often administered together with paclitaxel, docetaxel or aromatase inhibitor e.g. anastrozol. Common adverse reactions of trastuzumab that can be confused with an acute porphyric attack are vomiting and nausea. Side effects such as nausea and vomiting may be potentially porphyrinogenic through reduction in caloric intake.
Mono.MetabolismAndPharmacokinetics
Metabolized as endogenous IgG. Non-CYP metabolism.
Mono.PublishedExperience
Used uneventfully for the treatment of breast cancer in AIP woman (Kristiansen, 2006).
Mono.IpnetDrugReports
No.
Mono.SimilarDrugs
Mono.References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Treatment and treatment considerations in a patient with advanced breast cancer and acute intermittent porphyria.
Kristiansen C, Langkjer ST. Acta Oncol. 2006; 45(3):337-9.
|
16644579 |
| Drug reference publications | ||
| 2. | Sweetman SC, editor. Martindale: The complete drug reference. Trasuzumab. Pharmaceutical Press 2009.
|
|
| 3. | Trastuzumab.
McEvoy GK, editor. The AHFS Drug Information 2008. Bethesda, MD: American Society of Health-System Pharmacists; 2009. Electronic version (10.05.10).
|
|
| Summary of Product Characteristics | ||
| 4. | Norwegian medicines agency. Summary of Product Characteristics (SPC). Herceptin.
|
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Mono.Tradenames
Enhertu · Herceptin · Hercessi · Herzuma · Kadcyla · Kanjinti · Ogivri · Ontruzant · Trazimera 
Dazublys · Herceptin · Herwenda · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Tuznue · Zercepac 
Dazublys · Herceptin · Herwenda · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Tuznue · Zercepac 
Herceptin · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Zercepac 
Herceptin · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Zercepac 
Dazublys · Herceptin · Herwenda · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Tuznue · Zercepac 
Dazublys · Herceptin · Herwenda · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Tuznue · Zercepac 
Herceptin · Herzuma · Kanjinti · Ogivri · Trazimera · Zercepac 
Herceptin · Herclon · Herzuma · Kanjinti · Ogivri · Trazimera · Zercepac 
Herceptin · Herzuma · Kanjinti · Kanjinti 420mg powder for concentrate for solution for infusion vials · Ogivri · Ontruzant · Trastuzumab (Herceptin) 1029mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 105mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 1176mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 126mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 1323mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 147mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 176.4mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 210mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 252mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 294mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 336mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 378mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 42mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 441mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 46.2mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 504mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 54.6mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 588mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 63mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 651mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 735mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 75.6mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 88.2mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herceptin) 882mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 1029mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 105mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 1176mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 126mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 1323mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 147mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 176.4mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 210mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 252mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 294mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 336mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 378mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 42mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 441mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 46.2mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 504mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 54.6mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 588mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 63mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 651mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 735mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 75.6mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 88.2mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Herzuma) 882mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 1029mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 105mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 1176mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 126mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 1323mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 147mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 176.4mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 210mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 252mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 294mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 336mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 378mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 42mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 441mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 46.2mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 504mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 54.6mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 588mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 63mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 651mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 735mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 75.6mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 88.2mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Kanjinti) 882mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 1029mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 105mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 1176mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 126mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 1323mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 147mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 176.4mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 210mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 252mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 294mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 336mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 378mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 42mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 441mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 46.2mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 504mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 54.6mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 588mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 63mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 651mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 735mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 75.6mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 88.2mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Ontruzant) 882mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 1029mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 105mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 1176mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 126mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 1323mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 147mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 176.4mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 210mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 252mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 294mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 336mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 378mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 42mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 441mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 46.2mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 504mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 54.6mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 588mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 63mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 651mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 735mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 75.6mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 88.2mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Trazimera) 882mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 1029mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 105mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 1176mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 126mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 1323mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 147mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 176.4mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 210mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 252mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 294mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 336mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 378mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 42mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 441mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 46.2mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 504mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 54.6mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 588mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 63mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 651mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 735mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 75.6mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 88.2mg/250ml in Sodium chloride 0.9% infusion bags · Trastuzumab (Zercepac) 882mg/250ml in Sodium chloride 0.9% infusion bags · Trazimera · Zercepac 
Dazublys · Herceptin · Herwenda · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Tuznue · Zercepac 
Extempore L01FD01 Trastuzumab · Herceptin · Herzuma · Kanjinti · Ogivri · Ontruzant · Trastuzumab · Trazimera · Zercepac 
Herceptin · Ogivri 
Dazublys · Herceptin · Herwenda · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Tuznue · Zercepac 
Herceptin · Herclon · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera 
Trazher 
Herceptin · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera 
Herceptin · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Tuznue 
Dazublys · Herwenda · Tuznue · Zercepac 
Dazublys · Herceptin · Herwenda · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Tuznue · Zercepac 
Dazublys · Herceptin · Herwenda · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Tuznue · Zercepac 
Dazublys · Herceptin · Herwenda · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Tuznue · Zercepac 
Dazublys · Herceptin · Herwenda · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Tuznue · Zercepac 
Dazublys · Herceptin · Herwenda · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Tuznue · Zercepac 
Herceptin · Herzuma · Kanjinti · Ogivri · Trazimera 
Dazublys · Herceptin · Herwenda · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Tuznue · Zercepac 
Herceptin · Herwenda · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Zercepac 
Dazublys · Herceptin · Herwenda · Herzuma · Kanjinti · Ogivri · Ontruzant · Trazimera · Tuznue · Zercepac 
Herceptin · Herwenda · Herzuma · Kadcyla · Kanjinti · Ogivri · Ontruzant · Trastuzumab component of herceptin hylecta · Trastuzumab component of phesgo · Trazimera · Zercepac 
Trastuzumab · Trastuzumab beta