J01GB03 - Gentamicin |
Not porphyrinogenic |
NP |
Mono.Rationale
Aminoglycoside, not metabolised. Three references state non-porphyrinogenicity.
Mono.ChemicalDescription
Broadspectrum aminoglycoside antibiotic. Eliminated in unchanged form by glomerular filtration.
Mono.IpnetDrugReports
One very well documented report of an attack requiring hospitalisation and treatment with heme arginate in a 39 year old susceptible female with AIP. However the patient also had an infection with fever that just as well could have caused the attack. Uneventful use reported in 4 patients with acute porphyria.
Mono.SimilarDrugs
Mono.References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Porphyria Drug Lists | ||
| 2. | French List
Centre Français des Porphyries
|
|
| 3. | South African List
Porphyria South Africa No longer maintained
|
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Mono.Tradenames