D07AA02 - Hydrocortisone

Probably Not Porphyrinogenic

Rationale

Probably only insignificant absorption. Ligand to PXR. Substrate for CYPs 3A4, 3A7, 11 B2. Inducer and inhibitor (!) of CYP 3A4. Several references stating non-porphyrinogenicity.

Chemical description

Mild glucocorticoid 0.1 % ointment used in dermatology. Systemic exposure on application on large areas of the body.

Ipnet drug reports

Uneventful use reported in 8 patients with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes

D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, Weak (Group I)

References

#	Citation details	PubMed ID
1.	Management of acute attacks in the porphyrias. Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.	9554242
2.	Drugs in the acute porphyrias--toxicogenetic diseases. Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.	9074793
Porphyria Drug Lists
3.	South African List Porphyria South Africa No longer maintained
Other sources
4.	Porphyrin metabolism and the Porphyrias [Book Chapter] Tschudy DP, Lamon JM Bondy BK, Rosenberg LE (eds): Duncan's Diseases of Metabolism, Philadelphia, WB Saunders. 1980.

Tradenames

Show more details and information about the listed tradenames

Biocort (stx) · Dilucort · Hydrocortisone · Mylocort · Skin Calm · Stopitch · Vari-Hydrocortisone

Hydrocortison · Hydrocortison-vaselinecrème

Cremicort · Hydrocortisone · Pannocort

Calmiox · Dermosa Hidrocortisona

Hikomicron · Hydrocortison

Cortidro · Dermirit · Dermocortal · Foille Insetti · Lenirit · Sintotrat

Hidrocortizon

Sanadermil

Boots Bite and Sting Relief Hydrocortisone · Boots Derma Care Hydrocortisone · Derma Care Hydrocortisone · Dermacort hydrocortisone · Dioderm · Efcortelan · Exe-Cort Hydrocortisone · Hc45 Hydrocortisone · Hydrocortisone · Lanacort · Mildison Lipocream · Pinewood Bites and Stings Relief · Skincalm Hydrocortisone Bite and Sting Relief · Zenoxone