D07AA02 - Hydrocortisone

Probably not porphyrinogenic

PNP

Rationale

Probably only insignificant absorption. Ligand to PXR. Substrate for CYPs 3A4, 3A7, 11 B2. Inducer and inhibitor (!) of CYP 3A4. Several references stating non-porphyrinogenicity.

Chemical description

Mild glucocorticoid 0.1 % ointment used in dermatology. Systemic exposure on application on large areas of the body.

Ipnet drug reports

Uneventful use reported in 8 patients with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes D07A / D07AA or go back.

References

#	Citation details	PubMed ID
1.	Management of acute attacks in the porphyrias. Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.	9554242
2.	Drugs in the acute porphyrias--toxicogenetic diseases. Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.	9074793
Porphyria Drug Lists
3.	South African List Porphyria South Africa No longer maintained
Other sources
4.	Porphyrin metabolism and the Porphyrias [Book Chapter] Tschudy DP, Lamon JM Bondy BK, Rosenberg LE (eds): Duncan's Diseases of Metabolism, Philadelphia, WB Saunders. 1980.

Tradenames

Show more details and information about the listed tradenames

Biocort · Dilucort · Hydrocortisone · Mylocort · Skin Calm · Stopitch · Vari-Hydrocortisone

Hydrocortison · Hydrocortison-vaselinecrème

Cremicort · Hydrocortisone · Pannocort

Calmiox · Dermosa Hidrocortisona

Hikomicron · Hydrocortison

Cortidro · Dermirit · Dermocortal · Foille Insetti · Lenirit · Sintotrat

Hidrocortizon

Sanadermil

Boots Bite and Sting Relief Hydrocortisone · Boots Derma Care Hydrocortisone · Derma Care Hydrocortisone · Dermacort hydrocortisone · Dioderm · Efcortelan · Exe-Cort Hydrocortisone · Hc45 Hydrocortisone · Hydrocortisone · Lanacort · Mildison Lipocream · Pinewood Bites and Stings Relief · Skincalm Hydrocortisone Bite and Sting Relief · Zenoxone