C03CC01 - Etacrynic Acid |
Probably not porphyrinogenic |
PNP |
Mono.Rationale
CAVE: under revision. Water-soluble substance. Non-CYP metabolism. No data pointing to CYP-interaction.
Mono.ChemicalDescription
Etacrynic acid is not a sulfonamide congener unlike many other diuretics.
Mono.TherapeuticCharacteristics
Loop-diuretic, short acting.
Mono.MetabolismAndPharmacokinetics
Conjugation occurs in the liver with compounds containing sulfhydryl groups, such as cysteine and N-acetylcysteine. This seems to be the major metabolic pathway. Etacrynic acid is excreted both in the bile and the urine, partly unchanged and partly in the form of metabolites. An in vitro study with rat liver microsomes indicates oxidative metabolism via the CYP450-system. It is not known to which extent such metabolism occurs in man.
Mono.PreclinicalData
None. No data pointing to CYP-induction.
Mono.PersonalCommunication
None
Mono.PublishedExperience
NOne
Mono.SimilarDrugs
Mono.References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Rat liver microsomal lipid peroxidation produced during the oxidative metabolism of ethacrynic acid.
Yamamoto K, Masubuchi Y, et al. Pharmacol Toxicol. 2001 Apr; 88(4):176-80.
|
11322174 |
Mono.Tradenames
Uregyt 
Reomax 
Edecrin · Edecrina · Ethacrynic Acid · Reomax 
Edecril 
Edecrin · Ethacrynate 
Edecrin · Ethacrynic acid · Hydromedin · Reomax 
Acide etacrynique 
Acido etacrinico 
Etacrynic acid